Search results for " EGFR-T790M"

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The diagnostic accuracy of circulating tumor DNA for the detection of EGFR-T790M mutation in NSCLC: a systematic review and meta-analysis

2018

AbstractThis pooled analysis aims at evaluating the diagnostic accuracy of circulating tumor (ct) DNA for the detection of EGFR-T790M mutation in NSCLC patients who progressed after EGFR-TKIs. Data from all published studies, reporting both sensitivity and specificity of plasma-based EGFR-T790M mutation testing by ctDNA were collected by searching in PubMed, Cochrane Library, American Society of Clinical Oncology, European Society of Medical Oncology and World Conference of Lung Cancer meeting proceedings. A total of twenty-one studies, with 1639 patients, were eligible. The pooled sensitivity of ctDNA analysis was 0.67 (95% CI: 0.64–0.70) and the pooled specificity was 0.80 (95% CI: 0.77–0…

0301 basic medicineOncologyMalemedicine.medical_specialtyLung NeoplasmsctDNA EGFR-T790M NSCLCMutation Missenselcsh:MedicineCochrane LibraryLikelihood ratios in diagnostic testingArticleCirculating Tumor DNA03 medical and health sciencesAmino Acid Substitution; ErbB Receptors; Female; Humans; Male; Predictive Value of Tests; Carcinoma Non-Small-Cell Lung; Circulating Tumor DNA; Lung Neoplasms; Mutation Missense; Neoplasm Proteins0302 clinical medicinePredictive Value of TestsInternal medicineCarcinoma Non-Small-Cell LungmedicineHumansLung cancerNon-Small-Cell Lunglcsh:ScienceMultidisciplinaryReceiver operating characteristicbusiness.industryCarcinomalcsh:RArea under the curvemedicine.diseasePublisher CorrectionNeoplasm ProteinsErbB Receptors030104 developmental biologyAmino Acid Substitution030220 oncology & carcinogenesisPredictive value of testsMeta-analysisMutationDiagnostic odds ratioFemalelcsh:QMissensebusinessScientific Reports
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